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Dynamic SUMOylation Is Linked to the Activity Cycles of Androgen Receptor in the Cell Nucleus

Despite of the progress in the molecular etiology of prostate cancer, the androgen receptor (AR) remains the major druggable target for the advanced disease. In addition to hormonal ligands, AR activity is regulated by posttranslational modifications. Here, we show that androgen induces SUMO-2 and S...

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מידע ביבליוגרפי
Main Authors: Rytinki, Miia, Kaikkonen, Sanna, Sutinen, Päivi, Paakinaho, Ville, Rahkama, Vesa, Palvimo, Jorma J.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457344/
https://ncbi.nlm.nih.gov/pubmed/22890844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00753-12
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