Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption

Activation of oncogenes or inhibition of WEE1 kinase deregulates cyclin-dependent kinase (CDK) activity and leads to replication stress; however, the underlying mechanism is not understood. We now show that elevation of CDK activity by inhibition of WEE1 kinase rapidly increases initiation of replic...

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Main Authors: Beck, Halfdan, Nähse-Kumpf, Viola, Larsen, Marie Sofie Yoo, O'Hanlon, Karen A., Patzke, Sebastian, Holmberg, Christian, Mejlvang, Jakob, Groth, Anja, Nielsen, Olaf, Syljuåsen, Randi G., Sørensen, Claus Storgaard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457333/
https://ncbi.nlm.nih.gov/pubmed/22907750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00412-12
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