Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase

Maintenance of genome integrity is of critical importance to cells. To identify key regulators of genomic integrity, we screened a human cell line with a kinome small interfering RNA library. WEE1, a major regulator of mitotic entry, and CHK1 were among the genes identified. Both kinases are importa...

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Detalhes bibliográficos
Main Authors: Beck, Halfdan, Nähse, Viola, Larsen, Marie Sofie Yoo, Groth, Petra, Clancy, Trevor, Lees, Michael, Jørgensen, Mette, Helleday, Thomas, Syljuåsen, Randi G., Sørensen, Claus Storgaard
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835936/
https://ncbi.nlm.nih.gov/pubmed/20194642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200905059
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