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Transmembrane Protein Aptamers That Inhibit CCR5 Expression and HIV Coreceptor Function

We have exploited the ability of transmembrane domains to engage in highly specific protein-protein interactions to construct a new class of small proteins that inhibit HIV infection. By screening a library encoding hundreds of thousands of artificial transmembrane proteins with randomized transmemb...

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Detalhes bibliográficos
Main Authors: Scheideman, Elizabeth H., Marlatt, Sara A., Xie, Yanhua, Hu, Yani, Sutton, Richard E., DiMaio, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457321/
https://ncbi.nlm.nih.gov/pubmed/22811524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00910-12
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