Inhibition of α-ketoglutarate-and pyruvate dehydrogenase complexes in E. coli by a glutathione S-transferase containing a pathological length poly-Q domain: A possible role of energy deficit in neurological diseases associated with poly-Q expansions?

At least seven adult-onset neurodegenerative diseases, including Huntington’s disease (HD), are caused by genes containing expanded CAG triplets within their coding regions. The expanded CAG repeats give rise to extended stretches of polyglutamines (Q(n)) in the proteins expressed by the affected ge...

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Bibliographic Details
Main Authors: Cooper, Arthur J. L., Sheu, K-F. Rex, Burke, James R., Onodera, Osamu, Strittmatter, Warren J., Roses, Allen D., Blass, John P.
Format: Artigo
Language:Inglês
Published: Kluwer Academic Publishers 1998
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3455770/
https://ncbi.nlm.nih.gov/pubmed/23604331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-998-0004-x
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