Inhibition of α-ketoglutarate-and pyruvate dehydrogenase complexes in E. coli by a glutathione S-transferase containing a pathological length poly-Q domain: A possible role of energy deficit in neurological diseases associated with poly-Q expansions?

At least seven adult-onset neurodegenerative diseases, including Huntington’s disease (HD), are caused by genes containing expanded CAG triplets within their coding regions. The expanded CAG repeats give rise to extended stretches of polyglutamines (Q(n)) in the proteins expressed by the affected ge...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Cooper, Arthur J. L., Sheu, K-F. Rex, Burke, James R., Onodera, Osamu, Strittmatter, Warren J., Roses, Allen D., Blass, John P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Kluwer Academic Publishers 1998
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3455770/
https://ncbi.nlm.nih.gov/pubmed/23604331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-998-0004-x
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia