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Epigenetic genes regulated by the BRAFV600E signaling are associated with alterations in the methylation and expression of tumor suppressor genes and patient survival in melanoma

We have previously reported that the BRAFV600E signaling causes genome-wide aberrations in gene methylation in melanoma cells. To explore the potential molecular mechanisms for this epigenetic effect of BRAFV600E, in this in silico study we analyzed 11 microarray datasets retrieved from NCBI GEO dat...

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Detalhes bibliográficos
Main Authors: Liu, Dingxie, Liu, Xuan, Xing, Mingzhao
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3454505/
https://ncbi.nlm.nih.gov/pubmed/22820187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.07.046
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