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Inhibition of the Ubiquitin-Proteasome Activity Prevents Glutamate Transporter Degradation and Morphine Tolerance

Glutamate transporters play a crucial role in physiological glutamate homeostasis and neurotoxicity. Recently, we have shown that downregulation of glutamate transporters after chronic morphine exposure contributed to the development of morphine tolerance. In the present study, we examined whether r...

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Bibliografiske detaljer
Main Authors: Yang, Liling, Wang, Shuxing, Lim, Grewo, Sung, Backil, Zeng, Qing, Mao, Jianren
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3454498/
https://ncbi.nlm.nih.gov/pubmed/18986766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2008.09.028
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