Alpha-secretase inhibition reduces human glioblastoma stem cell growth in vitro and in vivo by inhibiting Notch

The Notch pathway is dysregulated and a potential target in glioblastoma multiforme (GBM). Currently available Notch inhibitors block γ-secretase, which is necessary for Notch processing. However, Notch is first cleaved by α-secretase outside the plasma membrane, via a disintegrin and metalloprotein...

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Sonraí Bibleagrafaíochta
Main Authors: Floyd, Desiree H., Kefas, Benjamin, Seleverstov, Oleksandr, Mykhaylyk, Olga, Dominguez, Charli, Comeau, Laurey, Plank, Christian, Purow, Benjamin
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2012
Ábhair:
Basic and Translational Investigations
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3452340/
https://ncbi.nlm.nih.gov/pubmed/22962413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos157
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