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Evidence for the multicentric origin of the sickle cell hemoglobin gene in Africa.

Previous studies of the Hpa I cleavage site-sickle cell hemoglobin gene linkage in various African populations suggested that the sickle gene arose independently more than once. In the present study we have performed restriction endonuclease haplotype analysis for the beta-globin-like gene cluster f...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Pagnier, J, Mears, J G, Dunda-Belkhodja, O, Schaefer-Rego, K E, Beldjord, C, Nagel, R L, Labie, D
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1984
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC345002/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6584911/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.6.1771
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