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A high-yielding serum-free, suspension cell culture process to manufacture recombinant adenoviral vectors for gene therapy
We have developed an efficient, reproducible, and scaleable cell culture process for a recombinant adenoviral vector expressing therapeutic transgenes for clinical trials. HEK 293 cells – which support the propagation of E1 deficient adenovirus – were first adapted to serum free media and suspension...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Kluwer Academic Publishers
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3449833/ https://ncbi.nlm.nih.gov/pubmed/19003410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1023/A:1008021428969 |
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