The paraoxonase-1 pathway is not a major bioactivation pathway of clopidogrel in vitro

BACKGROUND AND PURPOSE: Clopidogrel is a prodrug bioactivated by cytochrome P450s (CYPs). More recently, paraoxonase-1 (PON1) has been proposed as a major contributor to clopidogrel metabolism. The purpose of this study was to assess the relative contribution of CYPs and PON1 to clopidogrel metaboli...

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Detalhes bibliográficos
Main Authors: Ancrenaz, V, Desmeules, J, James, R, Fontana, P, Reny, J-L, Dayer, P, Daali, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448899/
https://ncbi.nlm.nih.gov/pubmed/22428615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01946.x
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