Genetic polymorphisms and drug interactions modulating CYP2D6 and CYP3A activities have a major effect on oxycodone analgesic efficacy and safety

BACKGROUND AND PURPOSE: The major drug-metabolizing enzymes for the oxidation of oxycodone are CYP2D6 and CYP3A. A high interindividual variability in the activity of these enzymes because of genetic polymorphisms and/or drug–drug interactions is well established. The possible role of an active meta...

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Detalhes bibliográficos
Main Authors: Samer, CF, Daali, Y, Wagner, M, Hopfgartner, G, Eap, CB, Rebsamen, MC, Rossier, MF, Hochstrasser, D, Dayer, P, Desmeules, JA
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935998/
https://ncbi.nlm.nih.gov/pubmed/20590588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00709.x
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