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Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis

BACKGROUND: A poor biological response to clopidogrel is associated with an increased risk of major cardiovascular ischemic events (MACE). Paraoxonase 1 (PON1) enzyme activity is modulated by the PON1-Q192R variant (rs662) and was recently suggested to be strongly involved in clopidogrel bioactivati...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: RENY, J.-L., COMBESCURE, C., DAALI, Y., FONTANA, P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750958/
https://ncbi.nlm.nih.gov/pubmed/22520065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2012.04756.x
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