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Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis

BACKGROUND: A poor biological response to clopidogrel is associated with an increased risk of major cardiovascular ischemic events (MACE). Paraoxonase 1 (PON1) enzyme activity is modulated by the PON1-Q192R variant (rs662) and was recently suggested to be strongly involved in clopidogrel bioactivati...

詳細記述

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書誌詳細
主要な著者: RENY, J.-L., COMBESCURE, C., DAALI, Y., FONTANA, P.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750958/
https://ncbi.nlm.nih.gov/pubmed/22520065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2012.04756.x
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