Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome

Programmed cell death or apoptosis is a prominent feature of low-risk myelodysplastic syndromes (MDS), although the underlying mechanism remains controversial. High-risk MDS have less apoptosis associated with increased expression of the prosurvival BCL2-related proteins. To address the mechanism an...

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Main Authors: Slape, Christopher I., Saw, Jesslyn, Jowett, Jeremy B. M., Aplan, Peter D., Strasser, Andreas, Jane, Stephen M., Curtis, David J.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2012
Teme:
Myeloid Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448259/
https://ncbi.nlm.nih.gov/pubmed/22855610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-05-430736
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