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Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma

NOTCH1 is frequently mutated in human precursor T-cell lymphoblastic leukemia/lymphoma (pre-T LBL). In the current study, we found that 13 of 19 cell lines and 29 of 49 primary tumors from SCL/LMO1, OLIG2/LMO1, OLIG2, LMO1, NUP98/HOXD13, and p27(-/-)/SMAD3(+/-) mice had Notch1 mutations in either th...

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Bibliografiske detaljer
Main Authors: Lin, Ying-Wei, Nichols, Rebecca A., Letterio, John J., Aplan, Peter D.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Hematology 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1414627/
https://ncbi.nlm.nih.gov/pubmed/16282337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-07-3013
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