A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma

The serine/threonine Pim kinases are up-regulated in specific hematologic neoplasms, and play an important role in key signal transduction pathways, including those regulated by MYC, MYCN, FLT3-ITD, BCR-ABL, HOXA9, and EWS fusions. We demonstrate that SMI-4a, a novel benzylidene-thiazolidine-2, 4-di...

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Bibliographische Detailangaben
Hauptverfasser: Lin, Ying-Wei, Beharry, Zanna M., Hill, Elizabeth G., Song, Jin H., Wang, Wenxue, Xia, Zuping, Zhang, Zhenhua, Aplan, Peter D., Aster, Jon C., Smith, Charles D., Kraft, Andrew S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2010
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941996/
https://ncbi.nlm.nih.gov/pubmed/19965690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-233445
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