p53 and miRNA-34 are Suppressors of Canonical Wnt Signaling

Although loss of p53 function and activation of canonical Wnt signaling cascades are frequently coupled in cancer, the links between these two pathways remain unclear. We report here that p53 transactivates miRNA-34 (miR-34), which suppresses the transcriptional activity of β-catenin-T-cell factor/l...

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Détails bibliographiques
Auteurs principaux: Kim, Nam Hee, Kim, Hyun Sil, Kim, Nam-Gyun, Lee, Inhan, Choi, Hyung-Seok, Li, Xiao-Yan, Kang, Shi Eun, Cha, So Young, Ryu, Joo Kyung, Na, Jung Min, Park, Changbum, Kim, Kunhong, Lee, Sanghyuk, Gumbiner, Barry M., Yook, Jong In, Weiss, Stephen J.
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447368/
https://ncbi.nlm.nih.gov/pubmed/22045851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001744
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