p53 and miRNA-34 are Suppressors of Canonical Wnt Signaling

Although loss of p53 function and activation of canonical Wnt signaling cascades are frequently coupled in cancer, the links between these two pathways remain unclear. We report here that p53 transactivates miRNA-34 (miR-34), which suppresses the transcriptional activity of β-catenin-T-cell factor/l...

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Detalhes bibliográficos
Main Authors: Kim, Nam Hee, Kim, Hyun Sil, Kim, Nam-Gyun, Lee, Inhan, Choi, Hyung-Seok, Li, Xiao-Yan, Kang, Shi Eun, Cha, So Young, Ryu, Joo Kyung, Na, Jung Min, Park, Changbum, Kim, Kunhong, Lee, Sanghyuk, Gumbiner, Barry M., Yook, Jong In, Weiss, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447368/
https://ncbi.nlm.nih.gov/pubmed/22045851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001744
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