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Group I p21-Activated Kinases (PAKs) Promote Tumor Cell Proliferation and Survival Through the AKT1 and Raf-MAPK Pathways

Group I p21-activated kinases (PAKs) are important effectors of the small GTPases Rac and Cdc42, which regulate cell motility/migration, survival, proliferation and gene transcription. Hyperactivation of these kinases have been reported in many tumor types, making PAKs attractive targets for therape...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Menges, Craig W., Sementino, Eleonora, Talarchek, Jacqueline, Xu, Jinfei, Chernoff, Jonathan, Peterson, Jeffrey R., Testa, Joseph R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447107/
https://ncbi.nlm.nih.gov/pubmed/22798428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-12-0082
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