Sirt5 Deacylation Activities Show Differential Sensitivities to Nicotinamide Inhibition

Sirtuins are protein deacylases regulating metabolism and aging processes, and the seven human isoforms are considered attractive therapeutic targets. Sirtuins transfer acyl groups from lysine sidechains to ADP-ribose, formed from the cosubstrate NAD(+) by release of nicotinamide, which in turn is a...

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Bibliographic Details
Main Authors: Fischer, Frank, Gertz, Melanie, Suenkel, Benjamin, Lakshminarasimhan, Mahadevan, Schutkowski, Mike, Steegborn, Clemens
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446968/
https://ncbi.nlm.nih.gov/pubmed/23028781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045098
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