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Sirt5 Deacylation Activities Show Differential Sensitivities to Nicotinamide Inhibition
Sirtuins are protein deacylases regulating metabolism and aging processes, and the seven human isoforms are considered attractive therapeutic targets. Sirtuins transfer acyl groups from lysine sidechains to ADP-ribose, formed from the cosubstrate NAD(+) by release of nicotinamide, which in turn is a...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3446968/ https://ncbi.nlm.nih.gov/pubmed/23028781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045098 |
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