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Sirt5 Deacylation Activities Show Differential Sensitivities to Nicotinamide Inhibition

Sirtuins are protein deacylases regulating metabolism and aging processes, and the seven human isoforms are considered attractive therapeutic targets. Sirtuins transfer acyl groups from lysine sidechains to ADP-ribose, formed from the cosubstrate NAD(+) by release of nicotinamide, which in turn is a...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Fischer, Frank, Gertz, Melanie, Suenkel, Benjamin, Lakshminarasimhan, Mahadevan, Schutkowski, Mike, Steegborn, Clemens
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446968/
https://ncbi.nlm.nih.gov/pubmed/23028781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045098
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