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Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7)

The pluripotency factor Lin28 recruits a 3′ terminal uridylyl transferase (TUTase) to selectively block let-7 microRNA biogenesis in undifferentiated cells. Zcchc11 (TUTase4/TUT4) was previously identified as an enzyme responsible for Lin28-mediated pre-let-7 uridylation and control of let-7 express...

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Bibliografiske detaljer
Main Authors: Thornton, James E., Chang, Hao-Ming, Piskounova, Elena, Gregory, Richard I.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446710/
https://ncbi.nlm.nih.gov/pubmed/22898984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.034538.112
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