The anti-CD74 humanized monoclonal antibody, milatuzumab, which targets the invariant chain of MHC II complexes, alters B-cell proliferation, migration, and adhesion molecule expression

INTRODUCTION: Targeting CD74 as the invariant chain of major histocompatibility complexes (MHC) became possible by the availability of a specific humanized monoclonal antibody, milatuzumab, which is under investigation in patients with hematological neoplasms. CD74 has been reported to regulate chem...

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Detalhes bibliográficos
Main Authors: Frölich, Daniela, Blaβfeld, Daniela, Reiter, Karin, Giesecke, Claudia, Daridon, Capucine, Mei, Henrik E, Burmester, Gerd R, Goldenberg, David M, Salama, Abdulagabar, Dörner, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446420/
https://ncbi.nlm.nih.gov/pubmed/22404985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3767
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