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Secondary structure specificity of the nuclease activity of the 1,10-phenanthroline-copper complex.

The artificial DNase activity of the 1,10-phenanthroline-cuprous ion complex [(OP)2Cu+] and H2O2 cleaves the A, B, and Z forms of DNA at different rates. The B structure, formed by most DNAs including poly(dA-dT) and poly(dA) X poly(dT), is the most susceptible to cleavage. It is completely degraded...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pope, L E, Sigman, D S
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1984
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC344598/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6320169/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.1.3
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