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Secondary structure specificity of the nuclease activity of the 1,10-phenanthroline-copper complex.

The artificial DNase activity of the 1,10-phenanthroline-cuprous ion complex [(OP)2Cu+] and H2O2 cleaves the A, B, and Z forms of DNA at different rates. The B structure, formed by most DNAs including poly(dA-dT) and poly(dA) X poly(dT), is the most susceptible to cleavage. It is completely degraded...

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Bibliographic Details
Main Authors: Pope, L E, Sigman, D S
Format: Artigo
Language:Inglês
Published: 1984
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC344598/
https://ncbi.nlm.nih.gov/pubmed/6320169
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