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Nuclease activity of 1,10-phenanthroline-copper: sequence-specific targeting.
The nuclease activity of 1,10-phenanthroline-copper ion can be targeted to specific DNA sequences by attachment of the ligand to the 5' end of complementary deoxyoligonucleotides via a phosphoramidate linkage. To synthesize the adduct, the phosphorimidazolide of the deoxyoligonucleotide is prep...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1986
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386672/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3020536/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.19.7147 |
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