The influence of reducing agent and 1,10-phenanthroline concentration on DNA cleavage by phenanthroline + copper.

Copper in the presence of excess 1,10-phenanthroline, a reducing agent, and molecular oxygen causes cleavage of DNA with a preference for T-3',5'-A-steps, particularly in TAT triplets. The active molecular species is commonly thought to be the bis-(1,10-phenanthroline)Cu(I) complex, (Phen)...

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Udgivet i:Nucleic Acids Res
Main Authors: Veal, J M, Merchant, K, Rill, R L
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1991
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC328338/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2062655/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/19.12.3383
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