B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer

Both the PI3K→Akt→mTOR and MAPK signaling pathways are often deregulated in prostate tumors with poor prognosis. Here we describe a new genetically-engineered mouse model of prostate cancer in which PI3K-Akt-mTOR signaling is activated by inducible disruption of PTEN, and ERK1/2 MAP kinase signaling...

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Detalhes bibliográficos
Main Authors: Wang, Jingqiang, Kobayashi, Takashi, Floc'h, Nicolas, Kinkade, Carolyn Waugh, Aytes, Alvaro, Dankort, David, Lefebvre, Celine, Mitrofanova, Antonina, Cardiff, Robert D., McMahon, Martin, Califano, Andrea, Shen, Michael M., Abate-Shen, Cory
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3445712/
https://ncbi.nlm.nih.gov/pubmed/22836754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-0820
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