Inhibition of IGF-IR tyrosine kinase induces apoptosis and cell cycle arrest in imatinib-resistant chronic myeloid leukaemia cells

Although signalling through the type I insulin-like growth factor receptor (IGF-IR) maintains the survival of haematopoietic cells, a specific role of IGF-IR in haematological neoplasms remains largely unknown. Chronic myeloid leukaemia (CML) is the most common subtype of chronic myeloproliferative...

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Autors principals: Shi, Ping, Chandra, Joya, Sun, Xiaoping, Gergely, Mate, Cortes, Jorge E, Garcia-Manero, Guillermo, Arlinghaus, Ralph B, Lai, Raymond, Amin, Hesham M
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2010
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444523/
https://ncbi.nlm.nih.gov/pubmed/19508387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2009.00795.x
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