Pharmacokinetics and Biodistribution of a Human Monoclonal Antibody to Oxidized LDL in Cynomolgus Monkey Using PET Imaging

PURPOSE: Oxidized low-density lipoprotein (LDL) plays an essential role in the pathogenesis of atherosclerosis. The purpose of this study was to characterize the pharmacokinetics (PK) of a human recombinant IgG1 antibody to oxidized LDL (anti-oxLDL) in cynomolgus monkey. The tissue biodistribution o...

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Main Authors: Kamath, Amrita V., Williams, Simon P., Bullens, Sherry, Cowan, Kyra J., Stenberg, Yvonne, Cherry, Simon R., Rendig, Stephen, Kukis, David L., Griesemer, Chris, Damico-Beyer, Lisa A., Bunting, Stuart
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444451/
https://ncbi.nlm.nih.gov/pubmed/23028793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045116
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