In Vivo Analysis of the Regulatory Genes in the Nystatin Biosynthetic Gene Cluster of Streptomyces noursei ATCC 11455 Reveals Their Differential Control Over Antibiotic Biosynthesis

Six putative regulatory genes are located at the flank of the nystatin biosynthetic gene cluster in Streptomyces noursei ATCC 11455. Gene inactivation and complementation experiments revealed that nysRI, nysRII, nysRIII, and nysRIV are necessary for efficient nystatin production, whereas no signific...

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Bibliografiska uppgifter
Huvudupphovsmän: Sekurova, Olga N., Brautaset, Trygve, Sletta, Håvard, Borgos, Sven E. F., Jakobsen, Øyvind M., Ellingsen, Trond E., Strøm, Arne R., Valla, Svein, Zotchev, Sergey B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2004
Ämnen:
Gene Regulation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC344421/
https://ncbi.nlm.nih.gov/pubmed/14973031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.186.5.1345-1354.2004
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