Characterization of the P450 Monooxygenase NysL, Responsible for C-10 Hydroxylation during Biosynthesis of the Polyene Macrolide Antibiotic Nystatin in Streptomyces noursei

The nysL gene, encoding a putative P450 monooxygenase, was identified in the nystatin biosynthetic gene cluster of Streptomyces noursei. Although it has been proposed that NysL is responsible for hydroxylation of the nystatin precursor, experimental evidence for this activity was lacking. The nysL g...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Volokhan, Olga, Sletta, Håvard, Ellingsen, Trond E., Zotchev, Sergey B.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Microbiology 2006
الموضوعات:
Enzymology and Protein Engineering
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC1449010/
https://ncbi.nlm.nih.gov/pubmed/16597951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.72.4.2514-2519.2006
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