New Nystatin-Related Antifungal Polyene Macrolides with Altered Polyol Region Generated via Biosynthetic Engineering of Streptomyces noursei

Polyene macrolide antibiotics, including nystatin and amphotericin B, possess fungicidal activity and are being used as antifungal agents to treat both superficial and invasive fungal infections. Due to their toxicity, however, their clinical applications are relatively limited, and new-generation p...

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Главные авторы: Brautaset, Trygve, Sletta, Håvard, Degnes, Kristin F., Sekurova, Olga N., Bakke, Ingrid, Volokhan, Olga, Andreassen, Trygve, Ellingsen, Trond E., Zotchev, Sergey B.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2011
Предметы:
Biotechnology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187132/
https://ncbi.nlm.nih.gov/pubmed/21764946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.05780-11
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