New Nystatin-Related Antifungal Polyene Macrolides with Altered Polyol Region Generated via Biosynthetic Engineering of Streptomyces noursei

Polyene macrolide antibiotics, including nystatin and amphotericin B, possess fungicidal activity and are being used as antifungal agents to treat both superficial and invasive fungal infections. Due to their toxicity, however, their clinical applications are relatively limited, and new-generation p...

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Bibliografski detalji
Glavni autori: Brautaset, Trygve, Sletta, Håvard, Degnes, Kristin F., Sekurova, Olga N., Bakke, Ingrid, Volokhan, Olga, Andreassen, Trygve, Ellingsen, Trond E., Zotchev, Sergey B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2011
Teme:
Biotechnology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187132/
https://ncbi.nlm.nih.gov/pubmed/21764946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.05780-11
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