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The solution structure of the prototype foamy virus RNase H domain indicates an important role of the basic loop in substrate binding
BACKGROUND: The ribonuclease H (RNase H) domains of retroviral reverse transcriptases play an essential role in the replication cycle of retroviruses. During reverse transcription of the viral genomic RNA, an RNA/DNA hybrid is created whose RNA strand needs to be hydrolyzed by the RNase H to enable...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3443672/ https://ncbi.nlm.nih.gov/pubmed/22962864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-9-73 |
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