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Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

TDP-43 is a multifunctional DNA/RNA-binding protein that has been identified as the major component of the cytoplasmic ubiquitin (+) inclusions (UBIs) in diseased cells of frontotemporal lobar dementia (FTLD-U) and amyotrophic lateral sclerosis (ALS). Unfortunately, effective drugs for these neurode...

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Bibliografiske detaljer
Main Authors: Wang, I-Fang, Guo, Bo-Shen, Liu, Yu-Chih, Wu, Cheng-Chun, Yang, Chun-Hung, Tsai, Kuen-Jer, Shen, Che-Kun James
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443184/
https://ncbi.nlm.nih.gov/pubmed/22932872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206362109
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