Modeling early bactericidal activity in murine tuberculosis provides insights into the activity of isoniazid and pyrazinamide

Standard tuberculosis (TB) treatment includes an initial regimen containing drugs that are both rapidly bactericidal (isoniazid) and sterilizing (rifampin and pyrazinamide), and ethambutol to help prevent the emergence of drug resistance. Antagonism between isoniazid and pyrazinamide has been demons...

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Hlavní autoři: Grosset, Jacques, Almeida, Deepak, Converse, Paul J., Tyagi, Sandeep, Li, Si-Yang, Ammerman, Nicole C., Pym, Alexander S., Wallengren, Kristina, Hafner, Richard, Lalloo, Umesh, Swindells, Susan, Bishai, William R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443175/
https://ncbi.nlm.nih.gov/pubmed/22927424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203636109
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