Modeling early bactericidal activity in murine tuberculosis provides insights into the activity of isoniazid and pyrazinamide

Standard tuberculosis (TB) treatment includes an initial regimen containing drugs that are both rapidly bactericidal (isoniazid) and sterilizing (rifampin and pyrazinamide), and ethambutol to help prevent the emergence of drug resistance. Antagonism between isoniazid and pyrazinamide has been demons...

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Bibliographische Detailangaben
Hauptverfasser: Grosset, Jacques, Almeida, Deepak, Converse, Paul J., Tyagi, Sandeep, Li, Si-Yang, Ammerman, Nicole C., Pym, Alexander S., Wallengren, Kristina, Hafner, Richard, Lalloo, Umesh, Swindells, Susan, Bishai, William R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443175/
https://ncbi.nlm.nih.gov/pubmed/22927424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203636109
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