Lysosomal dysfunction in Parkinson disease: ATP13A2 gets into the groove

Mutations in ATP13A2 (PARK9) cause an autosomal recessive form of early-onset parkinsonism with pyramidal degeneration and dementia called Kufor-Rakeb Syndrome (KRS). The ATP13A2 gene encodes a transmembrane lysosomal P5-type ATPase (ATP13A2) whose physiological function in mammalian cells, and henc...

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Bibliografiske detaljer
Main Authors: Dehay, Benjamin, Martinez-Vicente, Marta, Ramirez, Alfredo, Perier, Celine, Klein, Christine, Vila, Miquel, Bezard, Erwan
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
Fag:
Autophagic Punctum
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442887/
https://ncbi.nlm.nih.gov/pubmed/22885599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.21011
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