BAX channel activity mediates lysosomal disruption linked to Parkinson disease

Lysosomal disruption is increasingly regarded as a major pathogenic event in Parkinson disease (PD). A reduced number of intraneuronal lysosomes, decreased levels of lysosomal-associated proteins and accumulation of undegraded autophagosomes (AP) are observed in PD-derived samples, including fibrobl...

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Bibliografiske detaljer
Udgivet i:Autophagy
Main Authors: Bové, Jordi, Martínez-Vicente, Marta, Dehay, Benjamin, Perier, Celine, Recasens, Ariadna, Bombrun, Agnes, Antonsson, Bruno, Vila, Miquel
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2014
Fag:
Basic Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119069/
https://ncbi.nlm.nih.gov/pubmed/24686337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.28286
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