Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration

Parkinson disease (PD) is a progressive neurodegenerative disorder pathologically characterized by the loss of dopaminergic neurons from the substantia nigra pars compacta and the presence, in affected brain regions, of protein inclusions named Lewy bodies (LBs). The ATP13A2 gene (locus PARK9) encod...

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Bibliografske podrobnosti
Main Authors: Dehay, Benjamin, Ramirez, Alfredo, Martinez-Vicente, Marta, Perier, Celine, Canron, Marie-Hélène, Doudnikoff, Evelyne, Vital, Anne, Vila, Miquel, Klein, Christine, Bezard, Erwan
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386132/
https://ncbi.nlm.nih.gov/pubmed/22647602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112368109
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