Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration

Parkinson disease (PD) is a progressive neurodegenerative disorder pathologically characterized by the loss of dopaminergic neurons from the substantia nigra pars compacta and the presence, in affected brain regions, of protein inclusions named Lewy bodies (LBs). The ATP13A2 gene (locus PARK9) encod...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Dehay, Benjamin, Ramirez, Alfredo, Martinez-Vicente, Marta, Perier, Celine, Canron, Marie-Hélène, Doudnikoff, Evelyne, Vital, Anne, Vila, Miquel, Klein, Christine, Bezard, Erwan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2012
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386132/
https://ncbi.nlm.nih.gov/pubmed/22647602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112368109
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