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Elevation of transcription factor Islet-1 levels in vivo increases β-cell function but not β-cell mass
A decrease in the expression of Islet-1 (Isl-1), an islet transcription factor, has been reported in several physiological settings of reduced β-cell function. Here, we investigate whether an increased level of Isl-1 in islet cells can enhance β-cell function and/or mass. We demonstrate that transge...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3442817/ https://ncbi.nlm.nih.gov/pubmed/22595886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/isl.19982 |
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