Rad50 Zinc Hook Is Important for the Mre11 Complex to Bind Chromosomal DNA Double-stranded Breaks and Initiate Various DNA Damage Responses

The Mre11-Rad50-Nbs1 (MRN) complex plays critical roles in checkpoint activation and double-stranded break (DSB) repair. The Rad50 zinc hook domain mediates zinc-dependent intercomplex associations of MRN, which is important for DNA tethering. Studies in yeast suggest that the Rad50 zinc hook domain...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: He, Jing, Shi, Linda Z., Truong, Lan N., Lu, Chi-Sheng, Razavian, Niema, Li, Yongjiang, Negrete, Alejandro, Shiloach, Joseph, Berns, Michael W., Wu, Xiaohua
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2012
Gaiak:
DNA and Chromosomes
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442509/
https://ncbi.nlm.nih.gov/pubmed/22833675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.384750
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