α-Synuclein Induces Alterations in Adult Neurogenesis in Parkinson Disease Models via p53-mediated Repression of Notch1

Parkinson disease is characterized by the loss of dopaminergic neurons mainly in the substantia nigra. Accumulation of α-synuclein and cell loss has been also reported in many other brain regions including the hippocampus, where it might impair adult neurogenesis, contributing to nonmotor symptoms....

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Detalhes bibliográficos
Main Authors: Desplats, Paula, Spencer, Brian, Crews, Leslie, Pathel, Pruthul, Morvinski-Friedmann, Dinorah, Kosberg, Kori, Roberts, Scott, Patrick, Christina, Winner, Beate, Winkler, Juergen, Masliah, Eliezer
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442504/
https://ncbi.nlm.nih.gov/pubmed/22833673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.354522
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