Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells

The eukaryotic genome is replicated according to a specific spatio-temporal programme. However, little is known about both its molecular control and biological significance. Here, we identify mouse Rif1 as a key player in the regulation of DNA replication timing. We show that Rif1 deficiency in prim...

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Autores principales: Cornacchia, Daniela, Dileep, Vishnu, Quivy, Jean-Pierre, Foti, Rossana, Tili, Federico, Santarella-Mellwig, Rachel, Antony, Claude, Almouzni, Geneviève, Gilbert, David M, Buonomo, Sara B C
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442270/
https://ncbi.nlm.nih.gov/pubmed/22850673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.214
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