An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks

DNA replication fork stalling poses a major threat to genome stability. This is counteracted in part by the intra-S phase checkpoint, which stabilizes arrested replication machinery, prevents cell-cycle progression and promotes DNA repair. The checkpoint kinase Mec1/ATR and RecQ helicase Sgs1/BLM co...

Full description

Saved in:
Bibliographic Details
Main Authors: Hegnauer, Anna Maria, Hustedt, Nicole, Shimada, Kenji, Pike, Brietta L, Vogel, Markus, Amsler, Philipp, Rubin, Seth M, van Leeuwen, Fred, Guénolé, Aude, van Attikum, Haico, Thomä, Nicolas H, Gasser, Susan M
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442269/
https://ncbi.nlm.nih.gov/pubmed/22820947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.195
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items