Mnt Loss Triggers Myc Transcription Targets, Proliferation, Apoptosis, and Transformation

Myc oncoproteins are overexpressed in most cancers and are sufficient to accelerate cell proliferation and provoke transformation. However, in normal cells Myc also triggers apoptosis. All of the effects of Myc require its function as a transcription factor that dimerizes with Max. This complex indu...

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Bibliographic Details
Main Authors: Nilsson, Jonas A., Maclean, Kirsteen H., Keller, Ulrich B., Pendeville, Helene, Baudino, Troy A., Cleveland, John L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC344188/
https://ncbi.nlm.nih.gov/pubmed/14749372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.4.1560-1569.2004
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