Activation of the stress proteome as a mechanism for small molecule therapeutics

Various small molecule pharmacologic agents with different known functions produce similar outcomes in diverse Mendelian and complex disorders, suggesting that they may induce common cellular effects. These molecules include histone deacetylase inhibitors, 4-phenylbutyrate (4PBA) and trichostatin A,...

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Main Authors: Brose, Rebecca Deering, Shin, Gloria, McGuinness, Martina C., Schneidereith, Tonya, Purvis, Shirley, Dong, Gao X., Keefer, Jeffrey, Spencer, Forrest, Smith, Kirby D.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3441123/
https://ncbi.nlm.nih.gov/pubmed/22752410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds247
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