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Pharmacokinetics of salsalate and salicylic acid in normal and diabetic rats

The pharmacokinetics (PK) of salsalate (SS) and salicylic acid (SA) was assessed in normal Wistar and diabetic Goto-Kakizaki rats. Three PK studies were conducted: 1) PK of SA in normal rats after intravenous dosing of SA at 20, 40, 80 mg/kg. 2) PK of SS and SA in normal rats after oral dosing of SS...

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Hlavní autoři: Cao, Yanguang, DuBois, Debra C., Almon, Richard R., Jusko, William J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3440557/
https://ncbi.nlm.nih.gov/pubmed/22782506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdd.1797
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