Fragments of HdhQ150 Mutant Huntingtin Form a Soluble Oligomer Pool That Declines with Aggregate Deposition upon Aging

Cleavage of the full-length mutant huntingtin (mhtt) protein into smaller, soluble aggregation-prone mhtt fragments appears to be a key process in the neuropathophysiology of Huntington’s Disease (HD). Recent quantification studies using TR-FRET-based immunoassays showed decreasing levels of soluble...

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Dettagli Bibliografici
Autori principali: Marcellin, David, Abramowski, Dorothee, Young, Douglas, Richter, Jens, Weiss, Andreas, Marcel, Audrey, Maassen, Julia, Kauffmann, Muriel, Bibel, Miriam, Shimshek, Derya R., Faull, Richard L. M., Bates, Gillian P., Kuhn, Rainer R., Van der Putten, P. Herman, Schmid, Peter, Lotz, Gregor P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3440421/
https://ncbi.nlm.nih.gov/pubmed/22984513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044457
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